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Image Search Results
Journal: Molecular Therapy
Article Title: In Vivo Delivery of a DNA-Encoded Monoclonal Antibody Protects Non-human Primates against Zika Virus
doi: 10.1016/j.ymthe.2019.03.005
Figure Lengend Snippet: In Vivo Protection against ZIKV Challenge in Rhesus Macaques following the Administration of DMAb-ZK190 or Naive Control (A) Overview of the injection regimen in rhesus macaques. DMAbs were administered in 3 sequential administrations on days 0, 3, and 6, and serum was collected serially throughout the study. Macaques were challenged with 10 4 PFU ZIKV strain PRVABC59 on day 0. (B) DMAb-ZK190 (n = 5) serum human IgG levels during the course of the challenge experiment. (C) Naive control (n = 5) serum human IgG levels during the course of the challenge experiment. (D) Serum ZIKV viral loads in DMAb-ZK190-administered macaques following challenge (n = 5). (E) Serum ZIKV viral loads in naive control macaques following challenge (n = 5). For each experiment, “n” refers to biological replicates.
Article Snippet: Macaques were challenged at
Techniques: In Vivo, Control, Injection